Growth Hormone Secretagogues
GHRH and GHRPs play distinct roles in the regulation of growth hormone (GH) secretion. GHRH is a natural hormone produced by the hypothalamus that stimulates the pituitary gland to release GH in a pulsatile pattern. GHRPs, on the other hand, are synthetic compounds that mimic the action of ghrelin, a hormone that stimulates appetite and also plays a role in GH secretion. They work by binding to ghrelin receptors in the pituitary gland, triggering the release of stored GH. The combination of GHRH and GHRPs creates a synergistic effect, enhancing GH secretion beyond what either hormone alone can achieve. This dual activation results in greater GH secretion than either alone, making them valuable for optimizing GH output and addressing GH deficiency.
Tesamorelin
Tesamorelin is a synthetic analogue of growth hormone-releasing hormone (GHRH). It consists of 44 amino acids and mimics the natural signalling pathway that stimulates the pituitary gland to release growth hormone (GH). GHRH peptides were first seen as CJC-1295 however further advances have led us to Tesamorelin which is the only GHRH to gain FDA approval.
Ipamorelin
Ipamorelin is a pentapeptide that acts as a growth hormone secretagogue. It mimics the action of ghrelin, the "hunger hormone," by selectively binding to the growth hormone secretagogue receptor. This binding triggers the release of growth hormone from the pituitary gland, influencing various anabolic processes in the body. This can increase appetite.
Whilst promoting the growth of new muscle fibres and enhancing overall recovery from injuries (without significantly affecting cortisol levels) higher GH levels can contribute to better sleep, which also aids recovery. Research suggests that Ipamorelin may aide some aging processes contributing to enhanced vitality and well being. GHRP-2 and GHRP-6 were the first in this line of GHTRP's however both effected cortisol and prolactin levels.